saintfan-n-alex
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The Omar character is gay because he's based on a real-life dude that David Simon heard about.
A lot of the characters are based on real people. Stringer and Avon are based on a dude called Little Melvin, who actually plays the reverand on the show (you know, the guy who helps Bunny Colvin get medical aid in Amsterdam, who helps him get started in the school program on Season 4).
Jay Landsman, the fat dude in homicide, is actually based on Jay Landsman. The real Jay Landsman plays the cop who was Bunny Colvin's right hand man, who we saw Carver looking for advice from in Episode One the other night. That's the real life Jay Landsman (who wasn't a good enough Jay Landsman to play the role of Jay Landsman, lol).
There was a a guy named Bodie Barksdale who they used to help create the characters of Avon and Stringer as well. They also stole his name for the character Bodie Broddus, and of course, Avon & Deangelo Barksdale.
another character is Ed Norris, he is a homicide detective, he had a line in one show (the one where they had to call Bunk from the ballgame to come work a murder) he said something to the affect of 3 murders in one night, i love this city
he was the police commissioner for Baltimore and spent time in jail (6 mo) for improper dealings of city money - he plays himself by name, though only a detective not the commish - he has a radio show as well
http://www.hbo.com/thewire/cast/characters/edward_norris.shtml