COVID-19 Outbreak Information Updates (Reboot) [over 150.000,000 US cases (est.), 6,422,520 US hospitilizations, 1,148,691 US deaths.] (2 Viewers)

[Arathrael]

LMAO I just realized why you don't realize you are wrong. I didn't see it before because frankly I didn't think you would be so ignorant about basic biology. You are making cellular starvation and obstaining from food to be the same thing! OMG LMAO

You don't even understand your own damned article LMAO

Your article is about mitophogy and virus immunity...it literally has nothing to do with what we are talking about and ABSOLUTELY NOTHING to do with what enables autophogy or mitophogy LMAO

Going without food temporarily is not cellular starvation LMAO

I apologise for your confusion. But you're still, somehow, spectacularly missing the point.

Your claim was that "the traditional 3 meals and snacks prevents autophagy".

To show that's wrong, all that's necessary is to show that autophagy occurs in different scenarios, including ones that apply to normal conditions, when people do eat three meals and snacks. Which is what I've been doing. Repeatedly.

Or do you think viruses only utilize mitophagy to promote their survival when their host hasn't eaten three meals and snacks? Do you think autophagy occurring at basal levels means "at basal levels except when people have eaten three meals and snacks?"

Why are you so reluctant to acknowledge that normal eating doesn't prevent autophagy from occurring at all?

 

[Dago]

I apologise for your confusion. But you're still, somehow, spectacularly missing the point.

Your claim was that "the traditional 3 meals and snacks prevents autophagy".

To show that's wrong, all that's necessary is to show that autophagy occurs in different scenarios, including ones that apply to normal conditions, when people do eat three meals and snacks. Which is what I've been doing. Repeatedly.

Or do you think viruses only utilize mitophagy to promote their survival when their host hasn't eaten three meals and snacks? Do you think autophagy occurring at basal levels means "at basal levels except when people have eaten three meals and snacks?"

Why are you so reluctant to acknowledge that normal eating doesn't prevent autophagy from occurring at all?

So let's review
1) you know nothing about autophogy and don't understand that cellular starvation has nothing to do with fasting

2) I posted a peer reviewed article from 2020 outlining the role of fasting in autophagy

3) I have literally broken down the hormones involved (which you know nothing about)

4) and at this point your argument boils down to "because I said so"

It's just sad at this point. You dont know how autophagy works. You posted articles that you were unable to comprehend and misrepresented them due to your ignorance, and you are too insecure to admit it

 

[Arathrael]

So let's review

Since by 'review' you mean 'completely ignore the post you're quoting in favour of more misrepresentation and passive aggressive attacks,' let's not.

I think the post you've quoted is pretty clear and to the point, and it should be entirely evident to anyone by now - assuming there's anyone left who isn't far beyond caring at this point - that the fact autophagy still occurs in normal, fed, conditions and is not prevented by three meals and snacking is well supported, and clearly not "because I said so."

Heck, as I said before, your link supports that: "However, some studies demonstrated that mitophagy occurred both in fasting and fed state with no significant differences or may be induced in fed state".

That's the point of contention here. I'm not the subject. That is. Ignoring it in favour of launching personal attacks is not going to achieve anything.

 

[Arathrael]

I don't think I saw this posted, unless I missed it. The FT did an analysis projecting what the US's hospitalisation rate would have looked like, had vaccination kept up with the levels seen in other countries, like Denmark:



As usual, worth clicking through to the thread. There's also a graph of comparative case fatality rates:



It's still good relative to what it was without vaccination, but it's clear that lower vaccine uptake, at what might not seem that significant a difference if you're just eyeballing the figures, has a pretty significant impact in practice.

 

[Dago]

Since by 'review' you mean 'completely ignore the post you're quoting in favour of more misrepresentation and passive aggressive attacks,' let's not.

I think the post you've quoted is pretty clear and to the point, and it should be entirely evident to anyone by now - assuming there's anyone left who isn't far beyond caring at this point - that the fact autophagy still occurs in normal, fed, conditions and is not prevented by three meals and snacking is well supported, and clearly not "because I said so."

Heck, as I said before, your link supports that: "However, some studies demonstrated that mitophagy occurred both in fasting and fed state with no significant differences or may be induced in fed state".

That's the point of contention here. I'm not the subject. That is. Ignoring it in favour of launching personal attacks is not going to achieve anything.

I was looking for the part wear you manned up and admitted the articles you thought supported your OPINION had nothing to do with the subject and that you admitted that you were wrong in thinking cellular starvation had anything to do with fasting, but I don't see it.

Somehow I am not surprised

 

[Dago]

@Arathrael
I'm sure by now you have searched and know you are completely wrong but just in case...

Regulation of autophagy by amino acids and MTOR-dependent signal transduction - PMC

Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which ...

www.ncbi.nlm.nih.gov

Complete description on how certain amino acids trigger the body to produce the hormone mTOR which stops autophogy (including on a cellular level). How do we get amino acids? By consuming protein. Additionally, the article talks about how insulin stops autophagy. When does our body produce insulin? When we consume sugars and carbs.

Additionally I stated that AMPK is necessary to trigger autophagy as that signals the body not to produce mTOR

In other words, while your body is processing foods that cause it to produce insulin and mTOR (i.e. carbs and protein), autophagy does not happen.

Now are you ready to admit that your articles had nothing to do with the subject and you didn't understand what they were about or are you just going to keep up this charade because you are unable to admit you are wrong?

 

[Madmarsha]

sardines.

Great for Omega 3. Wish I could stomach the dang things.

 

[bclemms]

Took two years to get a decent study showing vitamin D levels prior to an infection and the eventual outcome after a covid infection but the data shows really strong correlations between low vitamin D and severe illness and death.

Vitamin D deficiency linked to severity, deaths among hospitalised Covid-19 patients: Study - Times of India

US News: WASHINGTON: A new study has found that low levels of vitamin D are associated with severe cases of Covid-19 as well as mortality.

timesofindia.indiatimes.com

 

[Goatman Saint]

Way back in once upon a time time there was talk of the vitamin D correlation to severe Covid. Glad to see they are making that connection stronger and hopefully moving it towards more mainstream. Vitamin D supplementation is super cheap, and if that’s one thing that can help, why not

 

[Dago]

Took two years to get a decent study showing vitamin D levels prior to an infection and the eventual outcome after a covid infection but the data shows really strong correlations between low vitamin D and severe illness and death.

Vitamin D deficiency linked to severity, deaths among hospitalised Covid-19 patients: Study - Times of India

US News: WASHINGTON: A new study has found that low levels of vitamin D are associated with severe cases of Covid-19 as well as mortality.

timesofindia.indiatimes.com

Way back in once upon a time time there was talk of the vitamin D correlation to severe Covid. Glad to see they are making that connection stronger and hopefully moving it towards more mainstream. Vitamin D supplementation is super cheap, and if that’s one thing that can help, why not

Yeah I thought that was out before the vaccines were available...that vitamin d helped regulate and prevent the cytokine storm

 

[Arathrael]

Way back in once upon a time time there was talk of the vitamin D correlation to severe Covid. Glad to see they are making that connection stronger and hopefully moving it towards more mainstream. Vitamin D supplementation is super cheap, and if that’s one thing that can help, why not

I kind of had it in my head that connection was already well established, because you're right, there was a lot of talk about it early on, there's been a lot of research published since the start (mixed, but overall pretty compelling) and enough compelling evidence early on for the NHS here to give a free fourth-month supply of vitamin D supplements to people at high risk from Covid-19 over winter 20/21.

But now I look, they didn't repeat that for this winter. My guess is they decided vaccination was sufficient, and possibly thought if they pushed vitamin D some proportion of people would mistakenly think vitamin D was an equal alternative to vaccination, rather than something complementary to reducing risk. Looks a lot like more of the 'vaccine only' approach, which I disagree with; vaccines are effective, and combining them with other measures adds more protection. Good communication can minimise the risk of people making bad decisions due to confusion.

Hopefully as the evidence becomes more compelling we'll see better messaging about it, since on the face of that evidence and some other recent studies, it could be saving lives.

 

[Goatman Saint]

That’s been my thought all along. I was vaccinated and boosted as soon as possible, made sure my family was also, and encouraged my friends as well as I could to do the same.

But to support that, I was very early a vitamin D taker, if nothing else than why not, exercise and eat mostly ok. While I know not one of those things is going to give me complete immunity, the combination of all has kept me from getting sick, even though my wife and I have had numerous exposures.

 

[SaintInBucLand]

Yeah I thought that was out before the vaccines were available...that vitamin d helped regulate and prevent the cytokine storm

Yeah I remembered that and found a post you made back in May of 2020 about Vitamin D.

COVID-19 Outbreak (Update: More than 2.9M cases and 132,313 deaths in US)

Okay so for those playing at home, tonight's thread de-railing will be: porn versus contact tracing.If you had that on your card, you can collect your prize at the SR Shop link above.

saintsreport.com

So it hasnt been peer reviewed, but it certainly doesnt hurt to get more Vitamin D

This One Supplement May Save You from COVID-19

A recently published medical study is showing a strong correlation between this key supplement and mortality rates that have come with the coronavirus: Vitamin D.

 

[bclemms]

I wasn't posting the Vitamin D as a breaking news sort of things. I've been on the Vitamin D bandwagon for a long time. It actually had a partial influence in our mapping early on and was part of the reason the mapping was directly tied to climate and the climate was directly tied to angle of the sun and latitudes combined with travel, population density and geopolitical issues. It was our theory on why Africa and tropical areas did unusually well with Covid up until Omicron (which was so contagious it just didn't give a damn about any other factors).

I was simply posting because it was the first study showing the vitamin D levels in people prior to infection and outcome. The study was fairly small but the given the 1400% difference between the two groups it's hard to imagine there isn't something there.

 

[DaveXA]

Yeah I remembered that and found a post you made back in May of 2020 about Vitamin D.

COVID-19 Outbreak (Update: More than 2.9M cases and 132,313 deaths in US)

Okay so for those playing at home, tonight's thread de-railing will be: porn versus contact tracing.If you had that on your card, you can collect your prize at the SR Shop link above.

saintsreport.com

So it hasnt been peer reviewed, but it certainly doesnt hurt to get more Vitamin D

This One Supplement May Save You from COVID-19

A recently published medical study is showing a strong correlation between this key supplement and mortality rates that have come with the coronavirus: Vitamin D.

Yeah, I think the benefits of Vitamin D are pretty clear, so while it certainly isn't a vaccine substitute, it's a good supplement. I got vaxxed and also been taking Vitamin D supplements. Just getting out in the sun helps too.