COVID-19 Outbreak Information Updates (Reboot) [over 150.000,000 US cases (est.), 6,422,520 US hospitilizations, 1,148,691 US deaths.] (33 Viewers)

[Arathrael]

So autophagy occurs when high blood sugar and insulin are present as well as glycogen in the liver?

I mean, I've said autophagy occurs at basal levels, I've said there are different forms of autophagy, some of them occur in nutrient rich scenarios, I've even given an example of SARS-CoV-2 inducing mitophagy, and I've linked to studies to back it up.

I'm just not sure how many other ways there are to say "starvation is not the only way autophagy is induced." Is there one you'll acknowledge? Or are we just wasting time here?

 

[Optimus Prime]

This is interesting.
===================

Some vital organs from patients who died from COVID-19 infection do not have evidence of the virus and can still be used for transplants, researchers from Johns Hopkins University said Monday.

After a donor died of complications related to COVID-19, one of their kidneys was successfully transplanted into another patient, according to the researchers. Before the transplant, “careful collection and sensitive molecular testing of the donor organ for evidence of the virus,” was conducted.

Testing demonstrated that the organ was safe to transplant, according to a summary for a peer-reviewed publication. Some autopsies have found high levels of virus receptors in kidneys, which indicates they could be a target area for COVID-19. These findings caused concern about using donor kidneys from COVID-19 patients, researchers explained.

Investigators from Johns Hopkins said this is the first documented case of a COVID-19 kidney transplant that included analysis of samples with sophisticated tools that can detect molecular evidence of the novel coronavirus, including the in situ hybridization laboratory technique. However, kidneys from deceased patients who were infected with the virus have been successfully used for transplants before............

A 55-year-old man with end-stage kidney disease received the donor’s kidney within 24 hours of her death. He had been on dialysis for more than five years, no history of COVID-19 infection and was fully vaccinated.

On the day of the transplant, he tested negative for the virus.

He also tested negative, 20, 30 and 90 days after the transplant procedure and has shown no signs or symptoms of COVID-19.

Additionally, the patient has been off dialysis and has excellent kidney function, researchers said............

MSN

www.msn.com

 

[LonghornSaint]

This is interesting.
===================

Some vital organs from patients who died from COVID-19 infection do not have evidence of the virus and can still be used for transplants, researchers from Johns Hopkins University said Monday.

After a donor died of complications related to COVID-19, one of their kidneys was successfully transplanted into another patient, according to the researchers. Before the transplant, “careful collection and sensitive molecular testing of the donor organ for evidence of the virus,” was conducted.

Testing demonstrated that the organ was safe to transplant, according to a summary for a peer-reviewed publication. Some autopsies have found high levels of virus receptors in kidneys, which indicates they could be a target area for COVID-19. These findings caused concern about using donor kidneys from COVID-19 patients, researchers explained.

Investigators from Johns Hopkins said this is the first documented case of a COVID-19 kidney transplant that included analysis of samples with sophisticated tools that can detect molecular evidence of the novel coronavirus, including the in situ hybridization laboratory technique. However, kidneys from deceased patients who were infected with the virus have been successfully used for transplants before............

A 55-year-old man with end-stage kidney disease received the donor’s kidney within 24 hours of her death. He had been on dialysis for more than five years, no history of COVID-19 infection and was fully vaccinated.

On the day of the transplant, he tested negative for the virus.

He also tested negative, 20, 30 and 90 days after the transplant procedure and has shown no signs or symptoms of COVID-19.

Additionally, the patient has been off dialysis and has excellent kidney function, researchers said............

MSN

www.msn.com

That's pretty interesting, although in situ analysis only uses a tiny amount of tissue, and I have concerns about their assumption that if that tiny sample is negative, therefore the whole organ is going to be negative.

 

[Optimus Prime]

That's pretty interesting, although in situ analysis only uses a tiny amount of tissue, and I have concerns about their assumption that if that tiny sample is negative, therefore the whole organ is going to be negative.

i wondered that too

But if he's still testing negative 3 months later, I assume that means he's completely in the clear

 

[faceman]

I guess this belongs here, I just got a call from my doc. My blood work came back. I dropped from 415 to 190 on
total cholesterol. I've given up alcohol , processed foods,red meat and other junk for six months. I've lived on veggies,cold water fish and legumes during this time. Forgive me for I'm about to celebrate with a foot long shrimp and oyster poboy fully dressed with blue plate mayo. YESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS

 

[LonghornSaint]

i wondered that too

But if he's still testing negative 3 months later, I assume that means he's completely in the clear

I hope so. I guess I need to read the primary literature on it when it comes out to have a better understanding of how thorough they are in vetting the organs.

It's possible they took many punches of tissue from all parts of the kidney for analysis.

 

[LonghornSaint]

I guess this belongs here, I just got a call from my doc. My blood work came back. I dropped from 415 to 190 on
total cholesterol. I've given up alcohol , processed foods,red meat and other junk for six months. I've lived on veggies,cold water fish and legumes during this time. Forgive me for I'm about to celebrate with a foot long shrimp and oyster poboy fully dressed with blue plate mayo. YESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS

Congrats, that's a big drop! Was it purely dietary intervention or are you on statins as well?

 

[SaintInBucLand]

Congrats, that's a big drop! Was it purely dietary intervention or are you on statins as well?

I bet it was all dietary changes. Statins are absolute garbage and have a sordid history of their development.

 

[faceman]

Congrats, that's a big drop! Was it purely dietary intervention or are you on statins as well?

yes diet and meds. I'm gonna skip the meds and go diet for 3 months and see how it goes. I'm a test subject for my doc lol

greens beans and sardines. The way to go for heart and liver health

 

[faceman]

let me add this for snacks. A handful of pecans or almonds are chock full of mono unsaturated fats. Those are the good
guys. They remove the plaque that builds up on the artery walls caused by LDL. Fark fasting. eat healthy and cheat from
time to time

 

[bonnjer]

let me add this for snacks. A handful of pecans or almonds are chock full of mono unsaturated fats. Those are the good
guys. They remove the plaque that builds up on the artery walls caused by LDL. Fark fasting. eat healthy and cheat from
time to time

Sounds like you've got some DASH diet type stuff going on there. It does work.

 

[sfidc3]

I guess this belongs here, I just got a call from my doc. My blood work came back. I dropped from 415 to 190 on
total cholesterol. I've given up alcohol , processed foods,red meat and other junk for six months. I've lived on veggies,cold water fish and legumes during this time. Forgive me for I'm about to celebrate with a foot long shrimp and oyster poboy fully dressed with blue plate mayo. YESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS

Way to go my friend. I'm on cholesterol meds as well, I was just over 300 and am now at about 210, I haven't made as drastic a change to my diet but it's a lot healthier than before....Cheers mate

 

[faceman]

Sounds like you've got some DASH diet type stuff going on there. It does work.

I became a diet nerd after i was diagnosed with high cholesterol. My diet requires some dedication

breakfast - peanut butter sandwich on whole grain bread with an orange. A perfectly balanced nutritional meal.

Lunch. 3.5 ounces of cold water fish, veggies, and beans.

Dinner- eat what you want and polish off with a bowl of oatmeal before bed

 

[faceman]

Way to go my friend. I'm on cholesterol meds as well, I was just over 300 and am now at about 210, I haven't made as drastic a change to my diet but it's a lot healthier than before....Cheers mate

add nuts and cold water fish mon frere. those are dynanite when it comes to lowering LDL

 

[Dago]

I mean, I've said autophagy occurs at basal levels, I've said there are different forms of autophagy, some of them occur in nutrient rich scenarios, I've even given an example of SARS-CoV-2 inducing mitophagy, and I've linked to studies to back it up.

I'm just not sure how many other ways there are to say "starvation is not the only way autophagy is induced." Is there one you'll acknowledge? Or are we just wasting time here?

Why are you being disingenuous?

I stated in one of my first posts that there is more than one way to induce autophagy so why do you keep pretending like I didn't?

Furthermore, my assertion is that in order to induce autophagy, one must have low blood sugar, low insulin, and have depleted glycogen stores in the liver.

So basic reading comprehension tells me that any activity that creates that state would induce autophagy...not just fasting.



However, it isn't just about inducing autophagy....it's about staying in it long enough to achieve benefits. Achieving autophagy thru exercise is meaningless if you immediately eat something that causes your body to create insulin (carbs) or mTOR (proteins) as both are anabolic processes that stops autophagy

In order for autophagy to start, Adenosine Tri Phosphate molecules have to lose a couple phosphates to become AMP which results in your body creating a hormone called AMPK and one of the things that AMPK does is act as a signaling switch to stop production of mTOR (which, like insulin, prevents autophagy)

so regardless of caloric intake, if what you eat stimulates the production of insulin or mTOR, then you won't have autophagy which is why fasting or intermittent fasting is the most effective way of having the sustained benefits of autophagy but certainly not the only way to put the body into a state of autophagy (at least for the average American). Cruciferous vegetables shouldn't cause the body to produce insulin or mTOR