COVID-19 Outbreak Information Updates (Reboot) [over 150.000,000 US cases (est.), 6,422,520 US hospitilizations, 1,148,691 US deaths.]

[Arathrael]

It worked extremely well for me, and many others I have met in my journey to find answers with long covid. Also I find your attempt to belittle autophagy induced by fasting by calling it starvation induced autophagy puerile and shows if you cannot come with intelligent discussion, instead you attack it with hyperbole.

As I've already pointed out, the problem is not you saying you think it worked for you, but your irrationally denying that other people found it made their symptoms worse.

And starvation-induced autophagy is a correct term for autophagy induced by starvation, amazingly enough. It's literal, not hyperbolic at all. See, for example: https://scholar.google.co.uk/schola...autophagy&hl=en&as_sdt=0&as_vis=1&oi=scholart

And your counter point to the studies I posted is comical, at no point did myself or Dago say that fasting works for everything, nice straw man to attack there. But what those studies DO show are many common metabolic health issues that have been shown to be improved with fasting.

If you're agreeing that fasting may be effective for some things, for some individuals, depending on their circumstances, but not for everything, you're going a really strange way about it.

And no, you can't take studies about "weight loss and type 2 diabetes risk reduction in overweight and obese populations" that conclude "more research is required before solid conclusions can be reached", for example, and conclude that fasting would be universally beneficial without risk of harm in patients with long Covid.

 

[Dago]

In my post responding to you, I cited the actual study to support what I said about it. When I said autophagy is far more complicated than you're suggesting, I linked to an overview of autophagy published in a peer-reviewed journal. That also substantiates that autophagy occurs at a basal level, and can be induced in multiple ways. And I linked to a recent study showing how viruses can induce mitophagy.

All of that you appear to have ignored.

Meanwhile, for your claim that starvation-induced autophagy would treat long Covid if it involves mitochondrial damage, and all your (largely inaccurate) claims about autophagy, you've given... a link to a press release about the award for the 2016 Nobel Prize in Physiology or Medicine, that you apparently didn't understand because it doesn't support anything you've said, stating as it does that autophagy also occurs in response to things other than starvation, and not, in any way, advocating for starvation-induced autophagy as therapy.

Your information is not current

1) You don't even know the basics in causing autophagy to occur. Caloric restriction is not what does it....one can restrict calories and still be eating foods that raise blood sugar and insulin. Glycogen in the liver must be depleted as well.

2) The study you posted is over 8 years old. Why would you choose to believe what is presented in a study done in 2014 while ignoring the more recent research I posted that won a Nobel Prize in 2018?

 

[Arathrael]

Your information is not current

1) You don't even know the basics in causing autophagy to occur. Caloric restriction is not what does it....one can restrict calories and still be eating foods that raise blood sugar and insulin. Glycogen in the liver must be depleted as well.

The information is current. I linked to that paper because it's a pretty comprehensive overview published in a peer reviewed journal. If you're going to assert that we've completely changed our understanding of autophagy since 2014, you're going to have to substantiate that.

And again, you're talking about starvation-induced autophagy, and again, autophagy occurs at basal levels and can be induced in other ways including in nutrient rich scenarios, which are not prevented by snacking.

2) The study you posted is over 8 years old. Why would you choose to believe what is presented in a study done in 2014 while ignoring the more recent research I posted that won a Nobel Prize in 2018?

...

The 2016 Nobel Prize was awarded to Yoshinori Ohsumi for his work in discovering mechanisms of autophagy which he carried out in the nineties.

Could you please stop? It's getting painful.

 

[Dago]

The information is current. I linked to that paper because it's a pretty comprehensive overview published in a peer reviewed journal. If you're going to assert that we've completely changed our understanding of autophagy since 2014, you're going to have to substantiate that.

And again, you're talking about starvation-induced autophagy, and again, autophagy occurs at basal levels and can be induced in other ways including in nutrient rich scenarios, which are not prevented by snacking.


...

The 2016 Nobel Prize was awarded to Yoshinori Ohsumi for his work in discovering mechanisms of autophagy which he carried out in the nineties.

Could you please stop? It's getting painful.

So autophagy occurs when high blood sugar and insulin are present as well as glycogen in the liver?

 

[Arathrael]

So autophagy occurs when high blood sugar and insulin are present as well as glycogen in the liver?

I mean, I've said autophagy occurs at basal levels, I've said there are different forms of autophagy, some of them occur in nutrient rich scenarios, I've even given an example of SARS-CoV-2 inducing mitophagy, and I've linked to studies to back it up.

I'm just not sure how many other ways there are to say "starvation is not the only way autophagy is induced." Is there one you'll acknowledge? Or are we just wasting time here?

 

[Optimus Prime]

This is interesting.
===================

Some vital organs from patients who died from COVID-19 infection do not have evidence of the virus and can still be used for transplants, researchers from Johns Hopkins University said Monday.

After a donor died of complications related to COVID-19, one of their kidneys was successfully transplanted into another patient, according to the researchers. Before the transplant, “careful collection and sensitive molecular testing of the donor organ for evidence of the virus,” was conducted.

Testing demonstrated that the organ was safe to transplant, according to a summary for a peer-reviewed publication. Some autopsies have found high levels of virus receptors in kidneys, which indicates they could be a target area for COVID-19. These findings caused concern about using donor kidneys from COVID-19 patients, researchers explained.

Investigators from Johns Hopkins said this is the first documented case of a COVID-19 kidney transplant that included analysis of samples with sophisticated tools that can detect molecular evidence of the novel coronavirus, including the in situ hybridization laboratory technique. However, kidneys from deceased patients who were infected with the virus have been successfully used for transplants before............

A 55-year-old man with end-stage kidney disease received the donor’s kidney within 24 hours of her death. He had been on dialysis for more than five years, no history of COVID-19 infection and was fully vaccinated.

On the day of the transplant, he tested negative for the virus.

He also tested negative, 20, 30 and 90 days after the transplant procedure and has shown no signs or symptoms of COVID-19.

Additionally, the patient has been off dialysis and has excellent kidney function, researchers said............

MSN

 

[LonghornSaint]

This is interesting.
===================

Some vital organs from patients who died from COVID-19 infection do not have evidence of the virus and can still be used for transplants, researchers from Johns Hopkins University said Monday.

After a donor died of complications related to COVID-19, one of their kidneys was successfully transplanted into another patient, according to the researchers. Before the transplant, “careful collection and sensitive molecular testing of the donor organ for evidence of the virus,” was conducted.

Testing demonstrated that the organ was safe to transplant, according to a summary for a peer-reviewed publication. Some autopsies have found high levels of virus receptors in kidneys, which indicates they could be a target area for COVID-19. These findings caused concern about using donor kidneys from COVID-19 patients, researchers explained.

Investigators from Johns Hopkins said this is the first documented case of a COVID-19 kidney transplant that included analysis of samples with sophisticated tools that can detect molecular evidence of the novel coronavirus, including the in situ hybridization laboratory technique. However, kidneys from deceased patients who were infected with the virus have been successfully used for transplants before............

A 55-year-old man with end-stage kidney disease received the donor’s kidney within 24 hours of her death. He had been on dialysis for more than five years, no history of COVID-19 infection and was fully vaccinated.

On the day of the transplant, he tested negative for the virus.

He also tested negative, 20, 30 and 90 days after the transplant procedure and has shown no signs or symptoms of COVID-19.

Additionally, the patient has been off dialysis and has excellent kidney function, researchers said............

MSN

That's pretty interesting, although in situ analysis only uses a tiny amount of tissue, and I have concerns about their assumption that if that tiny sample is negative, therefore the whole organ is going to be negative.

 

[Optimus Prime]

That's pretty interesting, although in situ analysis only uses a tiny amount of tissue, and I have concerns about their assumption that if that tiny sample is negative, therefore the whole organ is going to be negative.

i wondered that too

But if he's still testing negative 3 months later, I assume that means he's completely in the clear

 

[faceman]

I guess this belongs here, I just got a call from my doc. My blood work came back. I dropped from 415 to 190 on
total cholesterol. I've given up alcohol , processed foods,red meat and other junk for six months. I've lived on veggies,cold water fish and legumes during this time. Forgive me for I'm about to celebrate with a foot long shrimp and oyster poboy fully dressed with blue plate mayo. YESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS

 

[LonghornSaint]

i wondered that too

But if he's still testing negative 3 months later, I assume that means he's completely in the clear

I hope so. I guess I need to read the primary literature on it when it comes out to have a better understanding of how thorough they are in vetting the organs.

It's possible they took many punches of tissue from all parts of the kidney for analysis.

 

[LonghornSaint]

I guess this belongs here, I just got a call from my doc. My blood work came back. I dropped from 415 to 190 on
total cholesterol. I've given up alcohol , processed foods,red meat and other junk for six months. I've lived on veggies,cold water fish and legumes during this time. Forgive me for I'm about to celebrate with a foot long shrimp and oyster poboy fully dressed with blue plate mayo. YESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS

Congrats, that's a big drop! Was it purely dietary intervention or are you on statins as well?

 

[SaintInBucLand]

Congrats, that's a big drop! Was it purely dietary intervention or are you on statins as well?

I bet it was all dietary changes. Statins are absolute garbage and have a sordid history of their development.

 

[faceman]

Congrats, that's a big drop! Was it purely dietary intervention or are you on statins as well?

yes diet and meds. I'm gonna skip the meds and go diet for 3 months and see how it goes. I'm a test subject for my doc lol

greens beans and sardines. The way to go for heart and liver health

 

[faceman]

let me add this for snacks. A handful of pecans or almonds are chock full of mono unsaturated fats. Those are the good
guys. They remove the plaque that builds up on the artery walls caused by LDL. Fark fasting. eat healthy and cheat from
time to time